Complete 4 page APA formatted essay: Analog Circuit Computer Aided Design (CAD).

This section deals with the existing literatures related to analog circuit optimization. It outlines a summary of all the resource materials, authorial credentials, content credibility, source credibility, text credibility- Fluid integration of the source evaluation. A true literature review gives the proper sense of works that technology has achieved till date into that specified topic which helps one researcher to bring down his own research problem.

Han Young et al. (1990) developed an analog silicon compilation system for CMOS op amps (OPASYN). The synthesis starts from a certain specification. From its database, program selects op amp topology that suits most with the given specification. Using parametric optimization the circuit then determines optimal value for its parameters. It also produces Design-Rule-Correct compact layout of the optimized op amp.

Yang et al. (1995) proposed a Simulated Annealing (SA) algorithm for topology selection and sizing. In analog cells, topology choice and sizing simultaneously is efficient than normal two step mode synthesis. Basic problem with that approach is that super circuits must be worked out for each sort of analog cells.

Chen et al. (2000) placed an iterative optimization idea for improving delay in digital circuit. Instead of only adjusting that gate sizes to reduce delay, they adjusted wire loads of the gates by repositioning them using geometric program. It gave better result in deep sub-micron design where the effect of interconnect delays dominates

Mandal P and Visvanathan V (2001) devised an efficient technique for sizing of op amp by sequential convex optimization problem. This method then prototyped in MATLAB to apply into CMOS two stage op amp.

Complete 4 page APA formatted essay: Karyotyping (cellular chemistry).

DNA strands are systematically wound around several times over to permit storage without sacrificing the efficiency of regulated translation of the coded information into proteins, which are essential molecular components of biological processes (Gilbert 9). Defect in the highly-organized structure chromosomes will thus inhibit either the regulation of gene translation, or the translation process itself.

Karyotyping is the examination of chromosomes of a particular sample of cells to detect differences in the chromosomes’ number and structure. Cells may be obtained from amniotic fluid, blood, bone marrow, or placenta. As mentioned earlier, such aberrations manifests physically and functionally. For example, chromosomal aberration may affect fetal development, especially when the site of defect involves genes necessary for molding a child from a unicellular zygote. In such cases, either a couple cannot produce an offspring and continuously suffer miscarriages, or physical abnormalities and functional defects are evident after their baby is born. The abnormalities may manifest as soon as the baby has been delivered, or may take some time to be observed. In addition, chromosomal aberrations can also predispose someone to develop certain diseases, such as cancer (Chambers 2009).

When karyotyping was performed on a 28 year old male complaining of infertility, it was determined that he has an extra X chromosome, a condition known as Kleinfelter’s syndrome. This extra copy of X chromosome, specifically the genes that come with it, interferes with the proper function of testes in its production of viable sperm cells and testosterone. Each can exclusively cause the infertility experienced by the patient. Moreover, he might also have had small testes, large breasts, and reduced facial and body hair. The patient is also predisposed to developing breast cancer and systemic