Create a 8 pages page paper that discusses cystic fibrosis transplantaton. CF is inheritable and live threatening genetic disorder mostly experienced at the Northern European parts .To develop the disorder, one must inherit faulty gene from both of your parents this is by inheriting one set defective CFTR gene from the mother and the other from the father The disease is transmitted in a recessive way with chromosome 7. (Bush, 2006 )

It is caused due to anomaly in the cells producing mucus. A defect in CFTR gene causes the cystic fibrous, that alters the core function of the protein responsible of movement of salt and water in and out of body cells. (Komaroff, 2005)Through the scientific discovery transmembrane conductance regulator, called cystic fibrosis has greatly improved the understanding of the disorder and its diagnosis also showing the disease’s complexity. The study of the diseases started in 1946 but a fulgurating progress has been discovered in the recent years. (Hopkin, 2010).

Cystic Fibrous is common inheritable genetic disease within the Caucasian people in the U.S.A. From the research done the disease affects mostly the Northern European ancestry, although it too experienced at the parts of Hispanics, Native Americans. and some African-American the genetically inheritable diseases is affecting about 1 person in 17,000 African American,1 in 31,000 Asian American and large population affected being 1 in 2,000 to 3,5000. Cystic Fibrosis is an inherited disease that causes severe damages to the lungs, liver, sex organs, sinuses, pancreases, intestines, and sinuses. The disease is characterized by the buildup of sticky, thick mucus. (Moss, 1991)

Cystic Fibrosis is inherited diseases of the sweat glands and mucus. The mucus clogs the lungs as a result the breathing systems is affected and the mucus catalyze the growth of bacteria .

The Crown Bottling Company has just installed a new bottling process that will fill 16-ounce bottles of the popular Crown Classic Cola soft drink. Both overfilling and underfilling bottles are undesirable: Underfilling leads to customer complaints and overfilling costs the company considerable money. In order to verify that the filler is set up correctly, the company wishes to see whether the mean bottle fill, μ, is close to the target fill of 16 ounces. To this end, a random sample of 33 filled bottles is selected from the output of a test filler run. If the sample results cast a substantial amount of doubt on the hypothesis that the mean bottle fill is the desired 16 ounces, then the filler’s initial setup will be readjusted.

(b)Suppose that Crown Bottling Company decides to use a level of significance of α = 0.01, and suppose a random sample of 33 bottle fills is obtained from a test run of the filler. For each of the following four sample means—  = 16.05,  = 15.95,  = 16.06, and  = 15.99 — determine whether the filler’s initial setup should be readjusted. In each case, use a critical value, a p-value, and a confidence interval. Assume that σ equals .1. (Round your z to 2 decimal places and p-value to 4 decimal places and CI to 3 decimal places.)

 The Crown Bottling Company has just installed a new bottling process = 16.05

Z=

p=

Cl ( , )

 The Crown Bottling Company has just installed a new bottling process = 15.95

z=

p

Cl ( , )

 The Crown Bottling Company has just installed a new bottling process = 16.06

z=

p- value

Cl ( , )

 The Crown Bottling Company has just installed a new bottling process = 15.99

z=

p-value=

Cl ( , )